Technological innovations have a great influence on economic, social and political progress of modern society. A lot of factors foster progress of innovative development, andfactors of cooperation create an important group of them. When organizations and firms lack sources for generatinginnovations, they need help for meeting their goals. Cooperation helps realizing research and development projects and creating innovative products and services. It causes the problem of measuring and modeling innovative activity for regions with specific peculiarities. The problem may be solved by using regression models that allows examining the significance of the factors and obtaining the quantitative estimates of their influence on innovative development. As a source of relevant information data of Russian Federal State Statistics Service and OECD may be used.