This special issue presents extended texts of selected reports from the XII International Conference “Integrated Models and Soft Computing in Artificial Intelligence” (IMSC-2024), which was held in Kolomna, Russia, on May 14–17, 2024. The conference was co-organized by the Russian Association of Artificial Intelligence, the Association of Fuzzy Systems and Soft Computing, the Federal Research Center “Computer Science and Control” of the Russian Academy of Sciences, the Administration of the Kolomna Urban District, the Kolomna Institute of Moscow Polytechnic University, and the Institute of Computer Technology and Information Security of Southern Federal University. The scientific topics of the IMSC- 2024 conference covered the following relevant areas in artificial intelligence: fuzzy models, soft computing, measurements and evaluation in artificial intelligence; machine learning and neural network technologies; bioinspired approaches; cognitive models in artificial intelligence; data mining, knowledge and ontology engineering; hybrid intelligent systems; and intelligent agents, cyber–physical systems, intelligent manufacturing.