We consider some parameters of the astroclimate of two high-altitude observatories in Tajikistan—Sanglokh and Shorbulok. Long-term variations and seasonal features of the total cloud cover and the precipitated water vapor content are analyzed with the use of the ERA5 atmospheric reanalysis data (which is the fifth generation ECMWF reanalysis for the global climate and weather (where ECMWF stands for the European Centre for Medium-Range Weather Forecasts)). The trends observed since 1980 are estimated in terms of statistical significance. We present the results of measurements of the precipitated water vapor content and the near-surface wind speed at the Sanglokh observatory in 2024–2025.