The article gives the problem of resource assignment and performance optimisation in intelligent supply chain (ISC). The task of the resource assignment for intelligent supply chain is multi-product and multi-criterion task. Scale of the ISC determines the allocation of the suppliers and consumers of product. The customer demands for certain kind of product in ISC can be deemed as stochastic process. As goal of performance optimization task we should to evaluate parameters of ISC through assignment of production resources. The article presents the resource assignment model of ISC and its performance measures. On the base of simulation the verification and validation of presented model is carried out. The problem statement, solution method, numerical example and validation of model via simulation are represented for resource assignment and performance optimization model.