The work continues the research by the present authors on the management of industrial and infrastructure systems in accordance with the global trend in the digitalization of the economy. A description of the initial fundamental foundations of the ongoing developments and a review of domestic experience in the use of mathematical models, information and communication technologies, and large amounts of information in the management of systems are given. The issues of centralization and decentralization of control in complex systems are considered. Theoretical constructions of decision making are given to analyze the prospects for the development of partnership between the state and business within the framework of given legal norms. A block of conceptual models corresponding to the level of planning of large-scale organizational systems is given, issues of data preparation and development of algorithmic support, and a combination of macro- and micro-descriptions of economic systems are considered.