The paper considers a set of problems and trends related to the decommissioning of high-risk facilities, in particular nuclear power plants (NPP). Along with the traditional problems of ensuring nuclear and technological safety during the decommissioning of NPPs, new challenges have arisen related to ensuring cybersecurity. In accordance with the recommendations of regulatory documents, it is necessary to identify critical information assets at the design stage. The paper notes the need to create digital twins to develop technologies for decommissioning an object while ensuring its safety of all types. The paper discusses the areas of application of remote-control technologies and robotics during the decommissioning of nuclear power plants, and also highlights some of the problems of these technologies. The necessity of maintaining a knowledge base on the object, remote control of robots used for inspection and dismantling of the object, the use of artificial intelligence, ensuring cybersecurity, and the designing of digital twins is emphasized for the successful solution of the decommissioning problem.