The article presents the results of the foreign economic activity strategy development for the industrialized developed region in Russia. The authors analyzed the scenarios of socio-economic development of the country and identified the most promising sectors of the economy for the development of international activity. Based on these data, the conditions for the activation of exports are analyzed and a forecast is made for the development of foreign economic activity of the Chelyabinsk region as an industrial region with an industry structure in a conservative, base and target scenario. The authors proved that the growth of the export potential of the Russian regions is possible due to the development of existing enterprises and comprehensive support of innovative sectors of the economy.