Currently, the search for the mechanisms of increasing regional economic growth based on domestic factors became relevant. One promising source such growth is the transport infrastructure. The development of the road network infrastructure and transport centers can become a significant source of quality of life and economic activity, because transport infrastructure has the ability to spread of positive indirect effects. Indirect effects of transport infrastructure will be to the expansion of effects from enterprises embedded in interregional and international production chains to the local level. In the article due to econometric models author shows the relationship between regional economic growth and transport infrastructure level of development. At the same time, institutional terms and practices of strategic management can limit the opportunities of regional growth through these mechanisms. On the example of some socio-economic and infrastructural development programs of the Leningrad region of the Russian Federation one shows inconsistency in the infrastructure and socio-economic development guidelines. The proposed models allow to compare of strategic guidelines of different programs and makes it possible to justify some adjustments. These adjustments are necessary to chieve the benchmarks of socio-economic development. Generally, on the basis of the analy- sis it becomes possible to propose measures to improve the structure and content of socio-economic and infrastructural development programs of territories, which would allow more fully take into account the indirect effects which appeared in the development of transport infrastructure.