Heating, ventilation and air-conditioning (HVAC) systems maintain the indoor quality of air and temperature at acceptable levels in any building that hosts people. The amount of energy needed to operate these essential components of residential and commercial buildings is huge in the US, the EU and Russia as it is roughly half of the 40% of the primary energy resources consumed in these countries. Ensuring continued improvement of indoor environment quality while minimizing financial costs and accounting for requirements for energy efficiency that become more and more stringent to reduce the ecological footprint of energy consumption in buildings, present a formidable challenge on the scientific, engineering and business levels. Our project, which gathers a core team of Skoltech expert scientists, aims to finalize our energy efficient smart microclimate system and make it a marketable product, a cutting-edge solution for current needs in a developing, yet already quite competitive sector in Russia. The core of our approach is our physically-informed model predictive and data-driven control for all devices that govern indoor environments, and which we have successfully implemented and tested on recently built in a Skoltech teaching room. Bridging the gap between our laboratory results and their commercial application is our next exciting and timely challenge.