In the nuclear power engineering, methods of detecting anomalies, failures and diagnostics, as well as systems of information support of operators in the order of improving the safety and reliability of the operation play an increasing role. A task that is solving within the information support system is the task of calculating technical and economic indexes and its connection with the assurance of the normal operation mode of nuclear power plants. The technical and economic indexes characterize the efficiency, faultless, and durability of the power equipment in its operation process. By the information task of calculating the technical and economic indexes, objective information on the technological processes run efficiency, and actual power equipment is obtaining. Conditions of optimal NPP performance are determining in the process of its technical and economic indexes analysis. So, the analysis of these indexes is one of the most important tasks of the NPP APCS. The information task of calculating the technical and economic indexes in the realtime by the intelligent data analysis and models of predicting the risk potential of the critical infrastructure will enable one to prevent approaching the technological process to critical modes.