In the nuclear power engineering, methods of detection failures and diagnostics, as well as systems of information support of operators in the order of improving the safety and reliability of the operation play an increasing role. A task that is solved within the information support system is the task of calculating technical and economical indexes and its connection with the assurance of the normal operation mode of nuclear power plants. The technical and economical indexes characterize the efficiency, faultness, and durability of the power equipment in its operation process. On the basis of the information task of calculating the technical and economical indexes, objective information on the technological processes run efficiency and actual power equipment is obtained. Conditions of optimal NPP performance are determined in the process of its technical and economical indexes analysis. So, the analysis of these indexes is one of the most important tasks of the NPP APCS. The information task of calculating the technical and economical indexes in the real-time on the basis of the intelligent data analysis and models of predicting the risk potential of the critical infrastructure will enable one to prevent approaching the technological process to critical modes.