Автор(ы): Новочадов В. В. (?)Широкий А. А. (ИПУ РАН, Лаборатория 80)Автор(ов): 2 Параметры публикацииТип публикации: Статья в журнале/сборникеНазвание: Tissue engineering constructs for osteoarthritis treatment: a control of remodelingISBN/ISSN: 2310-6255DOI: 10.13187/ejmb.2016.13.104Наименование источника: European Journal of Molecular BiotechnologyОбозначение и номер тома: Ч. 13, № 3Город: СочиИздательство: Научный издательский дом ИсследовательГод издания: 2016Страницы: 104-113 АннотацияTissue engineering and regenerative medicine technologies (TERM technologies) remarkable progress allowed to use predominantly minimally invasive arthroscopic techniques to treat traumas and chronic joint diseases. The essence of joints tissue engineering is development and manufacturing bioengineering matrices (scaffolds) and their following implantation in cell-free variant, or previously populated by suitable cell pool to recover defects by a full-value 3D-structure. The important challenge here is to make individualized scaffolds, which properties are meet the requirements of person and his cartilage defect. The main objective of the study is to describe tissue engineering system “cartilage - scaffold” using systems biology and biocybernetics approaches. The task is to predict development of considered system through time and investigate the possibility to define and solve the control problem which could open the door for property-oriented scaffolds development. Authors explored the referred tissue engineering system as feedback-controlled system. Then we proposed the system of difference equations, which describe its dynamics. Results of computer simulation and forecasted values of extracellular matrix and cells volume ration are in physiological intervals and on a first approximation correspond with previously obtained experimental ones. The next step is to modify model for inverse solution of developing new generation of tissue engineering implants with predefined and controlled characteristics. Библиографическая ссылка: Новочадов В.В., Широкий А.А. Tissue engineering constructs for osteoarthritis treatment: a control of remodeling // European Journal of Molecular Biotechnology. 2016. Ч. 13, № 3. С. 104-113.