Chapter represents the methodological and applied issues of development the management processes of regional security. It describes the methodology of diagnosis, structural analysis and evaluation of the major threats to regional security. The problems of countering the destructive information effects based on misinformation and manipulation technologies are examined. The results of the analysis of the main features of the management processes of regional security are presented. There are the mechanisms of the use of scenario analysis in the management of socio-economic development of the region and ensuring its protection against external and internal threats to social stability. A formalized methodology to assess the effectiveness and efficiency of management of regional security is considered. The results of the scenario study investigation of multi-graph management models of regional security are given