Choline-containing preparations are used in the medical practice for treatment and prevention of the neurologic disorders of different genesis. We have used mathematical simulation to study the influence of the content of choline in the food ration of rats on the dynamics of the expression of nicotinic acetylcholine receptors of brain, as well as changes in the indices associated with the metabolism of choline in the organism – mass of the body of animals and amount of consumed food and water. The model was verified on the experimental data. The results of our work might be useful for developing a neuroprotection strategy based on the use of choline-containing preparations and minimizing the consequences of cerebral disorders after brain injury.