The new instrumentation and control (I&C) systems of the nuclear power plants (NPPs) improve the ability to operate the plant enhance the safety and performance of the NPP. However, they bring a new type of threat to the NPP's industry-cyber threat. The early fault diagnostic system (EDS) is one of the decision support systems that might be used online during the operation stage. The EDS aim is to prevent the incident/accident evolution by a timely troubleshooting process during any plant operational modes. It means that any significative deviation of plant parameters from normal values is pointed-out to plant operators well before reaching any undesired threshold potentially leading to a prohibited plant state, together with the cause that has generated the deviation. The paper lists the key benefits using the EDS to counter the cyber threat and proposes the framework for cybersecurity assessment using EDS during the operational stage.