With a method of mathematical modeling the relationship of certain indicators reflecting the relationship of content quantity of choline in food, the expression level of α7 nicotinic acetylcholine receptors in the brain, as well as mass bodies of animals their intake of food and water has been studied. Based on the received model a method for optimizing the use of choline-excess diet to more fully maintain cognitive functions of the brain and other indicators of the State of the organism in brain injury has developed. The developed model allowed obtaining qualitatively new information useful to interpret the data and to deepen notions about the mechanisms of the relationship of the above processes received. The results can be used for correction of brain disorders by using choline in experimental animal models and in the clinic