Abstract—The suggested approach for searching informative features of a pulse signal is based on sequential analysis of the characteristics of the waveform and the shape of rhythmic structure of the signal. At the first stage of the analysis, the pulse waveform is determined. The results allow the algorithm of the analysis of the rhythmic structure to be selected depending on the type of the pulse waveform. The difference of the analysis algorithms is caused by the fact that the type of the waveform determines the number of local parameters that affect the rhythmic structure. The suggested algorithm allows its parameters to be corrected at each stage of the analysis depending on the results of the previous stage. This gives the opportunity to take specific features of the pulse signal into account and, hence, improves the quality of recognition of diseases by the pulse analysis.